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      • This website is for UK Healthcare Professionals only

      This promotional material is intended for UK Healthcare Professionals experienced in the diagnosis and treatment of psoriasis and psoriatic arthritis. SKYRIZI® (risankizumab) and adalimumab prescribing information & adverse event reporting information can be found below.
      SKYRIZI DOSING GUIDE
      SKYRIZI PRESCRIBING INFORMATION
      ADALIMUMAB PRESCRIBING INFORMATION
      skyrizi desktop banner 7.0
      skyrizi mobile banner 2

      UK-RISN-230338. Date of preparation May 2024.

      Find out more about the efficacy of SKYRIZI

      Explore the durability of response with SKYRIZI through clinical trials and long-term data in psoriasis and psoriatic arthritis. Start by selecting a study from the menu below.

      LONG-TERM DATA

      SKYRIZI (LIMMitless)
      NMA data

      HEAD-TO-HEAD TRIALS

      SKYRIZI vs Secukinumab (IMMerge)
      SKYRIZI vs Ustekinumab (UltIMMa-1 + UltIMMa-2)
      SKYRIZI vs Adalimumab (IMMvent)

      SKYRIZI IN PsA

      KEEPsAKE1 + KEEPsAKE2

      SKYRIZI mode of action: Treat a cause, not an effect. Target a key driver of psoriatic inflammation.5-9

      SKYRIZI binds with high specificity to the p19 subunit of IL-23, causing prolonged down-regulation of pathogenetic Th17 cells, leading to a reduction of proinflammatory cytokines.5-9

      graph

      IL, interleukin; IFN-γ, interferon gamma; TGFβ, transforming growth factor beta; TH, T helper; TNFα, tumour necrosis factor alpha.

      Featured content

      The Retail Fitter 

      A retail fitter, who has been struggling with severe plaque psoriasis and early psoriatic arthritis, has found relief and almost complete skin clearance with SKYRIZI. As a result, he no longer worries about missing time at work. 

      How SKYRIZI works in 3 minutes

      In under 3 minutes, Dr Laura Savage explains how SKYRIZI inhibits the IL-12/Th17 pathway using a split milk carton analogy.

      More expert perspectives

      View expert perspectives on SKYRIZI’s efficacy
      data, dosing regimen and safety profile.

      View now

      More expert perspectives

      View expert perspectives on SKYRIZI’s efficacy data, dosing regimen and safety profile.

      View now

      UK-RISN-240179. Date of preparation May 2024.

      References

      1. Reich K, et al. Lancet 2019; 394: 576-586.
      2. Gordon KB, et al. Lancet 2018; 392: 650-661.
      3. Warren RB, et al. Risankizumab vs Secukinumab in Patients with Moderate-to-Severe Plaque Psoriasis: A Phase 3 Trial, Presented at AAD 2020.
      4. SKYRIZI: Summary of Product Characteristics.
      5. Gooderham MJ, et al. J Eur Acad Dermatol Venereol 2018; 32(7): 1111-1119.
      6. Kofoed K, et al. Acta Derm Venereol 2015; 95(2): 133-139.
      7. Gaffen SL, et al. Nat Rev Immunol 2014; 14(9): 585-600.
      8. Girolomoni G, et al. J Eur Acad Dermatol Venereol 2017; 31(1): 1616-1626.
      9. Lynde CW, et al. J Am Acad Dermatol 2014; 71(1): 141-150.

      UK-RISN-240143. Date of preparation: May 2024.

      SKYRIZI PRESCRIBING INFORMATION
      ADALIMUMAB PRESCRIBING INFORMATION

       

      Important safety information for SKYRIZI® (risankizumab) in Psoriasis and Psoriatic Arthritis¹
      SKYRIZI should be initiated and supervised by healthcare professionals experienced in the diagnosis and treatment of Psoriasis and Psoriatic arthritis.

      Some patients may not be suitable for SKYRIZI (risankizumab). You are strongly advised to read the prescribing information, which can be found at the top of this webpage and below, and the Summary of Product Characteristics (SmPC) which are available online in the Electronic Medicines Compendium (EMC) from the links below.

      SKYRIZI 150 mg solution for injection in pre-filled pen CLICK HERE.
      SKYRIZI 150 mg solution for injection in pre-filled syringe CLICK HERE.

      SKYRIZI PRESCRIBING INFORMATION CLICK HERE.

      SKYRIZI is contraindicated in patients;

      • with hypersensitivity to the active substance or to any of the excipients,
      • with clinically important active infections (e.g. active tuberculosis).

      Cautions (See Prescribing Information and SmPC for full details including screening and monitoring requirements):
      It is preferable to avoid the use of SKYRIZI during pregnancy. Women of childbearing potential should use an effective method of contraception during treatment and for at least 21 weeks after treatment. It is unknown whether risankizumab is excreted in human milk. A decision should be made whether to discontinue/abstain from risankizumab therapy, taking into account the benefit of breast-feeding to the child and the benefit of risankizumab therapy to the woman.

      Dosing in Psoriasis and Psoriatic Arthritis
      The recommended dose of SKYRIZI is 150mg administered by subcutaneous injection at Week 0, Week 4, and every 12 weeks thereafter.

      Adverse reactions
      For adverse reactions, please refer to the prescribing information and the SKYRIZI summary of product characteristics available online in the Electronic Medicines Compendium via the links above.

      Important safety information for HUMIRA® (adalimumab) in Psoriasis and Psoriatic Arthritis²
      HUMIRA is intended for use under the guidance and supervision of a physician experienced in the diagnosis and treatment of conditions for which HUMIRA is indicated.

      Psoriatic arthritis: HUMIRA is indicated for the treatment of active and progressive psoriatic arthritis in adults when the response to previous disease-modifying antirheumatic drug therapy has been inadequate. HUMIRA has been shown to reduce the rate of progression of peripheral joint damage as measured by X-ray in patients with polyarticular symmetrical subtypes of the disease and to improve physical function.
      Psoriasis: HUMIRA is indicated for the treatment of moderate-to-severe chronic plaque psoriasis in adult patients who are candidates for systematic therapy

      Paediatric plaque psoriasis: HUMIRA is indicated for the treatment of severe chronic plaque psoriasis in children and adolescents from 4 years of age who have had an inadequate response to or are inappropriate candidates for topical therapy and phototherapies.

      Some patients may not be suitable for HUMIRA. You are strongly advised to read the prescribing information, which can be found at the top of this webpage and below, and the Summary of Product Characteristics (SmPC) which are available online in the Electronic Medicines Compendium (EMC).

      HUMIRA 40 mg solution for injection in pre-filled pen CLICK HERE.

      ADALIMUMAB PRESCRIBING INFORMATION CLICK HERE.

      References
      1. SKYRIZI Summary of Product Characteristics
      2. HUMIRA Summary of Product Characteristics

      Adverse events should be reported. Reporting forms and information can be found at https://yellowcard.mhra.gov.uk or via the MHRA Yellow Card app, available in the Google Play or Apple App Stores. Adverse events should also be reported to AbbVie on GBPV@abbvie.com

       

      This website is for UK Healthcare Professionals only

      UK-ABBV-230225. Date of preparation June 2023. This website has been developed and funded by AbbVie Ltd.

      © 2023 AbbVie Ltd. All rights reserved. Registered Number: 08004972 England.