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    • This website is for UK Healthcare Professionals only

      This promotional material is intended for UK Healthcare Professionals experienced in the diagnosis and treatment of Chronic Migraine. BOTOX® (botulinum toxin type A) Prescribing Information and adverse event reporting information can be found below.

      +30 YEARS' GLOBAL EXPERIENCE
      ACROSS MULTIPLE INDICATIONS1-4

       

      CHRONIC MIGRAINE

      BOTOX® (botulinum toxin type A) is indicated for the prophylaxis of headaches in adults with chronic migraine (headaches on at least 15 days per month of which at least 8 days are with migraine).5

      +30 YEARS' GLOBAL EXPERIENCE ACROSS MULTIPLE INDICATIONS1-4

      CHRONIC MIGRAINE

      BOTOX® (botulinum toxin type A) is indicated for the prophylaxis of headaches in adults with chronic migraine (headaches on at least 15 days per month of which at least 8 days are with migraine).5

      NHS Rightcare has developed a toolkit for optimising a headache and migraine care system6

      The RightCare Headache and Migraine Toolkit: a pathway to provide clinicians with expert practical advice and guidance in order to:

      • Address the challenges of migraine and headache prevalence, and the associated disability and impact on productivity
      • Improve healthcare economics around migraine and headache
      • Benefit the patient by reducing unnecessary healthcare visits and improving overall outcomes

      The toolkit identifies four priorities for system improvement. Explore the following diagram to discover the key areas for focus in each priority:

      System improvement priorities6

      Correct identification and diagnosis
      of headache disorders

      Making appropriate referrals
      to secondary care

      Support patients to self-manage their
      condition after diagnosis

      Long-term management of patients in
      primary or community care


      The NHS Getting It Right First Time review of neurology gives recommendations for the management of common and chronic neurological disorders, including headache


      CM: chronic migraine.

       

      References

      1. AbbVie Data on file. Approval Dates for BOTOX® in UK. UK-BTX-230044. April 2023
      2. Allergan. Data on file. INT/0423/2016
      3. Aurora S K, Winner P et al. Onabotulinum toxin A for treatment of chronic migraine: pooled analyses of the 56-week PREEMPT clinical program. Headache. 2011;51(9):1358-1373
      4. Blumenfeld A M, Stark R J et al. Long-term study of the efficacy and safety of Onabotulinum toxin A for the prevention of chronic migraine: COMPEL study. J Headache Pain. 2018;19(1):13
      5. BOTOX® Summary of Product Characteristics. Available from: https://www.medicines.org.uk/emc/product/859/smpc.
      6. NHS RightCare. Headache and Migraine Toolkit optimising a headache and migraine system. Available at: england.nhs.uk. Accessed January 2025

       

      References

      1. AbbVie Data on file. Approval Dates for BOTOX® in UK. UK-BTX-230044. April 2023
      2. Allergan. Data on file. INT/0423/2016
      3. Aurora S K, Winner P et al. Onabotulinum toxin A for treatment of chronic migraine: pooled analyses of the 56-week PREEMPT clinical program. Headache. 2011;51(9):1358-1373
      4. Blumenfeld A M, Stark R J et al. Long-term study of the efficacy and safety of Onabotulinum toxin A for the prevention of chronic migraine: COMPEL study. J Headache Pain. 2018;19(1):13
      5. BOTOX® Summary of Product Characteristics. Available from: https://www.medicines.org.uk /emc/product/859/smpc.
      6. NHS RightCare. Headache and Migraine Toolkit optimising a headache and migraine system. Available at: england.nhs.uk. Accessed January 2025

      Please refer to the BOTOX® Summary of Product Characteristics for further information on adverse events, contraindications and special warnings and precautions for use. The BOTOX® Summary of Product Characteristics can be found here

      By clicking the link above you will leave the AbbVie Pro website and be taken to the eMC PI portal website.

      Adverse events should be reported. Reporting forms and information can be found at https://yellowcard.mhra.gov.uk/ 

      Adverse events should also be reported to AbbVie on GBPV@abbvie.com 

       

      Date of preparation: January 2025. UK-BCM-240127.

       

       

      IDENTIFICATION AND DIAGNOSIS6

      Healthcare practitioners to be supported and educated on the presenting symptoms of primary headache disorders (migraine, tension-type headache, cluster headache) and medication overuse headache:

      • To include utilising clinical champions and learning sessions

      Patients to be given a positive diagnosis of a primary headache disorder after being assessed against standardised criteria:

      • Use standardised assessment criteria, and provide an explanation of the diagnosis to the patient with reassurance that other pathologies have been excluded

      Where a primary diagnosis cannot be made initially (and after the exclusion of secondary headaches) diagnostic decision making should be made over time by the application of a headache diary.

      Prescribing information and adverse event reporting

      By clicking the link above you will leave the AbbVie Pro website and be taken to the eMC PI portal website.

      Reference: 6. NHS RightCare. Headache and Migraine Toolkit optimising a headache and migraine system. Accessed January 2025

      APPROPRIATE SECONDARY CARE REFERRALS6

      Patients should only be referred to secondary care for further investigation if their symptoms fall outside of the standard classification of primary headache disorders.

      Education and awareness of healthcare practitioners on the signs of medication overuse headache (MOH) that do not require referral into secondary care:

      • To include training on signs of MOH and common features of primary headache disorders such as migraine

      Consider implementation of referral support services to provide advice to healthcare professionals on the appropriateness of headache referrals to specialist outpatient neurology services.

      Prescribing information and adverse event reporting

      By clicking the link above you will leave the AbbVie Pro website and be taken to the eMC PI portal website.

      Reference: 6. NHS RightCare. Headache and Migraine Toolkit optimising a headache and migraine system. Accessed January 2025

      SELF-MANAGEMENT AFTER DIAGNOSIS6

      Promote the use of headache diaries to understand personal triggers.

      Provide information and education to people with a primary headache disorder on the risks and signs of developing medication overuse headache (MOH).

      Utilise pharmacists to provide patient advice on MOH and appropriate use of analgesics.

      Support the education of employers on the impact and effect of migraine at work:

      • Encourage communication between patient and employer and provide letters of diagnosis if required

      Signpost people to third-sector resources including local support groups or national advice lines to reduce attendance at A&E departments.

      Prescribing information and adverse event reporting

      By clicking the link above you will leave the AbbVie Pro website and be taken to the eMC PI portal website.

      Reference: 6. NHS RightCare. Headache and Migraine Toolkit optimising a headache and migraine system. Accessed January 2025

      LONG-TERM MANAGEMENT IN PRIMARY OR COMMUNITY CARE6

      Undertake shared decision-making with the patient on treatment options, including prophylactic treatment.

      Personalised care plans to be agreed and in place:

      • Take into account individual needs and preferences, as well as comorbidities/ other risk factors

      Manage primary headache disorders in primary or community settings and prescribe medication in line with NICE guidance:

      • Understand what services are available within the community, and ensure community-based services have sufficient training and support to manage patients with primary headache disorders

      Refer patients to a community headache clinic or a GPwSI if they become resistant to treatment:

      • Define referral criteria and have a clear referral pathway

      GPwSI: GP with special interest

      Prescribing information and adverse event reporting

      By clicking the link above you will leave the AbbVie Pro website and be taken to the eMC PI portal website.

      Reference: 6. NHS RightCare. Headache and Migraine Toolkit optimising a headache and migraine system. Accessed January 2025